In a model experiment, the effect of polymer sorbents of different origins on the content of mobile species of heavy metals (HM) in zonal soils of the East European Plain was examined in a case study using soils of the Tula Region. Both synthetic and natural sorbents were used: hydrolyzed polyacrylonitrile (HYPAN), a binary structure of HYPAN and potassium humate (Humate “Sakhalinsky”), and a fungi mycelium powder (Micosorbent A). The experiment was conducted on four types of agricultural soils (Umbric Albeluvisols, Greyic Phaeozems, Voronic Chernozems) sampled in the Tula region in 2024 and spiked with Cu+2, Zn+2, Pb+2, and Cd+2 salts in 6 threshold limit values (TLV). It has been established that the same sorbent showed a significantly different remediation effect on different soil types with the same level of metal contamination: copper was bind from 30% on Voroic Chernozems to 50% on Greyic Phaeozems soils. For lead, the highest percent of mobile species to total was observed in Umbric Albeluvisoils (72%) and the lowest in Voronic Chernozems (56%). The application of Alternaria alternata mycelium had an effective effect on the sorption of zinc and cadmium in the studied soils: up to 70% in Voroic Chernozems for cadmium and up to 85% in Umbric Albeluvisoils for zinc.